Important fact regarding Local Anesthetics — Pharmacology: Esters = metabolized by pseudocholinesterase. Amides = liver metabolized. Lidocaine (amide) = gold standard. Onset order: Fastest → Articaine > Lidocaine > Bupivacaine. pKa determines onset (lower pKa = faster onset).

This fact is from Local Anesthetics — Pharmacology in General & Dental Pharmacology. It is a commonly tested concept in NEET MDS examinations. Understanding this fact is crucial for answering MCQs correctly.

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More Facts from Local Anesthetics — Pharmacology

Esters = metabolized by plasma pseudocholinesterase = procaine

Amides = metabolized in liver = lidocaine

Lidocaine = gold standard LA = 2 percent most common

Onset determined by pKa = lower pKa faster onset

Duration determined by protein binding = higher binding longer duration

Articaine = unique hybrid amide with ester group

Prilocaine = least toxic amide

Bupivacaine = most cardiotoxic.