Pharmacology • NEET MDS
Esters = metabolized by plasma pseudocholinesterase = procaine.
Amides = metabolized in liver = lidocaine.
Lidocaine = gold standard LA = 2 percent most common.
Onset determined by pKa = lower pKa faster onset.
Duration determined by protein binding = higher binding longer duration.
Articaine = unique hybrid amide with ester group.
Prilocaine = least toxic amide.
Bupivacaine = most cardiotoxic.
Use these mnemonics during your revision. The key associations above are designed to help you recall LA Pharmacology concepts instantly during the exam. Focus on the “equals” associations — these are the most commonly tested patterns in NEET MDS.