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Bleeding Disorders

General Medicine • NEET MDS Study Guide • AI-Generated Notes

⭐ High-Yield Facts for Exam

  • Hemophilia A = Factor VIII; B = Factor IX.
  • vWD = most common inherited bleeding disorder.
  • PT/INR = extrinsic pathway (warfarin).
  • aPTT = intrinsic pathway (heparin).
  • Use factor replacement/DDAVP + local haemostasis.

Bleeding Disorders

  • Hemophilia A — deficiency of Factor VIII (X-linked).
  • Hemophilia B (Christmas disease) — deficiency of Factor IX.
  • von Willebrand disease — the most common inherited bleeding disorder (defective vWF → platelet adhesion + carries Factor VIII).

Lab Tests

  • PT (prothrombin time) — extrinsic pathway; monitored as INR for warfarin.
  • aPTT — intrinsic pathway; prolonged in hemophilia and with heparin.
  • Bleeding time/platelet function for vWD and platelet disorders.

Dental Care

Coordinate factor replacement/desmopressin and use local haemostatic measures.

Exam Tips ⭐

Hemophilia A = Factor VIII; B = Factor IX; vWD = most common inherited; PT/INR = extrinsic (warfarin); aPTT = intrinsic (heparin).

📝 Practice MCQs — Bleeding Disorders

Q1. Hemophilia A is a deficiency of:
A. Factor IX
B. Factor VIII
C. Factor VII
D. vWF
Show Answer
✅ Answer: B
Hemophilia A = Factor VIII deficiency.
Q2. The most common inherited bleeding disorder is:
A. Hemophilia A
B. Hemophilia B
C. von Willebrand disease
D. ITP
Show Answer
✅ Answer: C
Von Willebrand disease is the most common inherited bleeding disorder.
Q3. PT/INR primarily monitors the:
A. Intrinsic pathway/heparin
B. Extrinsic pathway/warfarin
C. Platelet count
D. Fibrinolysis
Show Answer
✅ Answer: B
PT/INR assesses the extrinsic pathway and warfarin therapy.
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