Fibro-osseous & Bone Lesions — NEET MDS | CrackMDS

Fibrous dysplasia. Fibrous dysplasia shows ground glass and a GNAS mutation.

Cherubism. Cherubism causes bilateral mandibular lesions (SH3BP2).

Alkaline phosphatase. Serum alkaline phosphatase is markedly raised in Paget's.

⭐ High-Yield Facts for Exam

Fibrous dysplasia — ground-glass radiograph, ill-defined margins, GNAS mutation; monostotic or polyostotic (McCune-Albright).
Ossifying fibroma — a well-demarcated benign fibro-osseous neoplasm (contrasts with fibrous dysplasia's blending margins).
Cherubism — bilateral mandibular expansion ('eyes raised to heaven'), SH3BP2 mutation, familial; regresses with age.
Paget's disease — cotton-wool bone, elevated alkaline phosphatase, hypercementosis.

Ground glass + GNAS = fibrous dysplasia; well-demarcated = ossifying fibroma; bilateral mandible = cherubism; cotton wool + ↑ALP = Paget's.

Q1. A 'ground-glass' radiographic appearance with GNAS mutation suggests:

A. Ossifying fibroma

B. Fibrous dysplasia

C. Paget's disease

D. Cherubism

Show Answer

✅ Answer: B

Fibrous dysplasia shows ground glass and a GNAS mutation.

Q2. Bilateral mandibular expansion in a child ('cherubic' face) suggests:

A. Cherubism

B. Paget's

C. Osteosarcoma

D. Fibrous dysplasia

Show Answer

✅ Answer: A

Cherubism causes bilateral mandibular lesions (SH3BP2).

Q3. Paget's disease typically shows elevated:

A. Amylase

B. Alkaline phosphatase

C. Calcium only

D. Bilirubin

Show Answer

✅ Answer: B

Serum alkaline phosphatase is markedly raised in Paget's.

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