Biopsy Techniques
- Incisional biopsy — removes a representative portion (with a margin of normal tissue) of a large or suspicious lesion for diagnosis before definitive treatment.
- Excisional biopsy — removes the entire lesion; suited to small (<1 cm), benign-appearing lesions (both diagnostic and therapeutic).
- FNAC (fine-needle aspiration cytology) — for deep masses, salivary glands and lymph nodes.
- Brush biopsy — a screening/cytology tool for suspicious mucosal lesions (positive result needs scalpel confirmation).
Principles
Take representative tissue, avoid necrotic centres, orient and fix the specimen properly (10% formalin), and include a margin where indicated.
Exam Tips ⭐
Incisional = large lesions; excisional = small (<1 cm); FNAC = deep/lymph node/salivary; brush = screening.